The Regulation of Ketogenesis from Octanoic Acid

The Regulation of Ketogenesis from Octanoic Acid

The regulation of ketogenesis in the rat has been studied both in uiuo and in the isolated perfused liver with octanoic acid as substrate. This fatty acid, which is not utilized directly for triglyceride synthesis, was chosen in order to investigate the events that govern the metabolism of fatty acids subsequent to the (?-oxidation process. Experiments in viuo established that for any given loa...

Regulation of hepatic fatty acid oxidation and ketogenesis.

Mechanisms for the regulation of ketogenesis.

Under optimum conditions mammalian metabolism is integrated so as to attain the most appropriate ‘mixture’ of circulating substrates for the prevailing dietary and physiological state of the animal. The regulatory mechanisms for integration are exerted at two levels, within the cell (intracellular integration) and between the various tissues (inter-organ integration). Integration is usually ach...

Regulation of ketogenesis in the liver.

Three major regulatory steps can be recognized in the control of ketogenesis (Fig. 1): (1) regulation of the supply of the major ketogenic substrate, plasma non-esterified fatty acids, by control of their release from adipose tissue; (2) regulation in the liver of the relative fluxes of non-esterified fatty acids through the pathways of /3-oxidation and esterification; (3) regulation in the liv...

C octanoic acid breath test

Although scintigraphy, a non-invasive procedure, is usually considered to be the reference technique for measuring gastric emptying in humans, several drawbacks limit its application in routine practice. Expensive equipment is required and access to a nuclear medicine department, and the use of radioactive isotopes (generally Tc and In) can produce low but significant irradiation. It is diYcult...